Transferosome: A Transdermal Vesicular Drug Delivery for the Treatment of Skin Cancer

Abstract

Transferosomes are ultra-deformable vesicles for transdermal applications consisting of a lipid bilayer with phospholipids, edge activator.The ratios of individual surfactants and the total amount of surfactants control the vesicle flexibility.For a few days now, emerging drug delivery innovations have created new interest in the development of drug delivery.TDDS is the drug delivery to the skin.This offers many possible advantages over conventional pathways, such as limiting first-pass metabolism, predictable and sustained period of action, reducing unnecessary side effects, using short half-life products, improving physiological and pharmacological response.In this review, the detailed study of  the transferosomes loaded topical preparations  with anticancer drugs like 5-fluorouracil,cisplatin etc and to characterize the parameters like drug entrapment, skin permeation, drug content, vesicle morphology, penetration ability, invitro drug release,invivo study and physical stability are discussed.