Polymorphism of CYP1A1 Gene and the variation in rs4646903, rs1048943 that occurs of Cervical Cancer in Iraq

Abstract

Background: Cervical cancer is a type of cancer which occurs due to the abnormality in the cervix cells. Objective: this study aimed to inspect the relationship between cervical cancer risk and the polymorphism of CYP1A1 gene. Materials and Methods: 80 females were selected in this study (40 patients with cervical cancer, and 40 normal considered as control group), the age mean was 40±15.2 for the patients and 39±14.9 for control group, this study was achieved in Alwayia Hospital for Gynecology and Obstetrics, Baghdad for the period (December, 2019 to April, 2020). SNP polymorphism and the risk of cervical cancer were investigated in both individuals. SNP-SNP was analyzed by the means of GMDR (Generalized Multifactor Dimensionality Reduction). Results: the OR (95%CI), and the odds intended to were carried out to find the relation between rs1048943 and rs4646903 such as GG or AG of rs1048943, and CC or TC OF rs4646903 genotypes which the researchers expect to have main risk for cervical cancer, and then the results were compared with AA, and TT, and it was found that the combination of rs104893 and rs4646903 will give a validation of 100/100, while the accuracy of test was 0.5989, and the p-value was 0.0105. Conclusions: there is association between cervical cancer and the variant genotypes, and there is opportunity of interference that CC or TC subjects, and GG or AG that belongs to rs4646903 and rs108943 respectively.