Influence of Cytokine Polymorphisms on the Chronicity of Viral Hepatitis HBV and HCV

Abstract

In recent years, special importance has been attached to the role of polymorphism of cytokine genes - important participants in the immunopathogenesis of viral hepatitis, which determine the nature of the interaction of the pathogen and the macroorganism, affect the chronicity of HBV and HCV infections, and modify the rate of fibrogenesis in the liver. Based on the study of gene polymorphism, it became possible with a high degree of probability to predict the predisposition to the development of viral hepatitis C and the state of resistance. The review presents convincing data on the association of single nucleotide substitutions with the peculiarities of the course of viral hepatitis, on the effect of polymorphism of the genes of cytokines IL-1β, IL-6 and TNFα on the pathogenesis of chronic HBV and HCV infection, response to treatment, and development of complications.